“Saving lives through education,
   advances in treatment, and
finding a cure for Barth syndrome”

Research Grant Program

2017 Request for Research Proposals

The Barth Syndrome Foundation, Inc. (BSF) and its international affiliates announce the availability of funding for basic science and clinical research on the natural history, biochemical basis, and treatment of Barth syndrome. There are two basic categories: IDEA grants for 1-2 years and DEVELOPMENT grants for 2-3 years with budgetary maximums of US $50,000 or $100,000, respectively. Although BSF will consider any research proposal related to Barth syndrome, it is particularly interested in supporting research in the areas identified by REQUEST FOR APPLICATIONS (RFAs) that are posted on its website. RFAs for work in clinical/scientific areas that BSF considers to be high priority areas of investigation may have increased budgetary maximums and other requirements (see the BSF website for details about any RFAs). Applications responding to RFAs will be given preferential consideration in the BSF Research Grant Program.

BSF's Research Grant Program now requires all applicants to be independent investigators (e.g., faculty appointment). Postdoctoral fellows cannot apply. BSF allows young, non-tenured investigators to include in their submitted budget up to 75% of the total grant amount as PI salary. In addition, for those clinical applications where volunteers must travel to a clinical research site, these travel expenses will be handled separately and will be excluded from the budget maximums mentioned above. We encourage independent investigators at all professional levels to submit their best ideas. There are no geographical limitations to this funding.

Background

Barth syndrome (BTHS) is a serious X-linked genetic condition associated with cardiomyopathy, neutropenia, skeletal muscle weakness, exercise intolerance, growth delay, and diverse biochemical abnormalities (including defects in mitochondrial metabolism and phospholipid biosynthesis). Because many clinical and biochemical abnormalities of Barth syndrome remain poorly understood, we are seeking proposals for both basic science and clinical research that may shed light on any aspect of the syndrome with the object of developing a specific treatment or a cure.

Types of Proposals Sought

We are interested in providing “seed grant funding” to young investigators as well as attracting experienced investigators new to the field of Barth syndrome basic science or clinical research. We anticipate that these funds will be used for the testing of initial hypotheses and the collection of preliminary data leading to successful long-term funding by the National Institutes of Health (NIH) and other major granting institutions around the world.

Process

BSF has a competitive grant process. In general terms, detailed information about the specific aims, significance, research design and methods, personnel, facilities, and budget will be required. A one-page, “Letter of Intent” is required for DEVELOPMENT grant applicants, and has a due date of September 7, 2017. The “Letter of Intent” is optional for IDEA grant applicants. We strongly encourage the submission of letters of intent before the due date to allow ample time.

Completed applications (and/or “letters of intent”) will be forwarded to the BSF Scientific and Medical Advisory Board (as well as to expert outside reviewers) for confidential evaluation. Response to the “Letter of Intent” will be communicated within two weeks of receipt. Based on the recommendations of the BSF Scientific and Medical Advisory Board, the BSF Board of Directors will make the final funding decisions about the grant applications. Once the final funding decisions are made, BSF affiliates will decide which, if any, of the approved grants they would like to fund. Please review our “Grants Awarded” webpage for a listing of grants that BSF and its affiliates have awarded to date.

Funding

We anticipate awarding several IDEA and DEVELOPMENT grants each year. Funds will be available soon after the successful grant applicants have been notified in late February, 2018.

Deadline

The deadline for submission of the completed research grant application is October 31, 2017, and grants will be awarded in late February, 2018. The deadline for the one-page "Letter of Intent," if applicable, is September 7, 2017.

Contact Information

Matthew J. Toth, PhD
Science Director
Barth Syndrome Foundation, Inc.
matthew.toth[at]barthsyndrome.org
mtothbsf[at]comcast.net
bsfinfo[at]barthsyndrome.org
Toll Free: 855-662-2784 (855-NO-BARTH)
Local Line: 914-303-6323

Download information:

Barth Syndrome International

 

Families of Barth

Derek

Meet Derek

Privacy and Disclaimer

Barth Syndrome Foundation does not endorse any drugs, tests, or treatments that we may report.

This website is for informational purposes, always check with your physician before adopting any medical treatment.

© Barth Syndrome Foundation. All rights reserved.
Web Design by Pixelera